Abstract
Aim: To evaluate the treatments used in patients diagnosed with
SARS-CoV-2 infection hospitalized in critical care service, through a
prescription indication study. Methods: A longitudinal observational
study of medication use, of the indication-prescription type with
elements of the therapeutic scheme and practical consequences, was
carried out. The sample was characterized from the sociodemographic,
clinical, and pharmacotherapeutic points of view. The prescription was
evaluated through the indicators: indication, therapeutic scheme,
treatment individualization, and drug combinations. The detected adverse
reactions were classified according to their causality by the Naranjo
Algorithm, their severity, their clinical significance, and according to
their mechanism by Rawlins and Thompson. Results: In the sample (N=77),
the male gender predominated (79%) between 27-59 years old (64%),
alcohol consumer (62%), hypertensive (33%) with long hospital stay
(51%). 417 medications were analyzed, being antibiotics (50.6%) being
the most prescribed. 73.4% of the therapeutic schemes were correct,
however, 26.6% had problems with the therapeutic schemes due to the use
of incorrect doses, intervals, and duration of treatment, as well as
risky interactions. Two probable adverse reactions were detected, mild,
non-serious, and type A and B according to Rawlins and Thompson.
Conclusions: The results obtained will allow the pharmaceutical
professional to create risk matrices that guarantee a timely
intervention in the health team to contribute to the rational and safe
use of medicines in patients infected with SARS-CoV-2.