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BRAF Mutation in Neuroblastoma: A Case Report of a Rare Finding
  • +2
  • Sara Hutchins,
  • Sara Ferguson R,
  • Geling Li,
  • Elizabeth Beierle,
  • Elizabeth Alva
Sara Hutchins
The University of Alabama at Birmingham Division of Hematology and Oncology

Corresponding Author:[email protected]

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Sara Ferguson R
The University of Alabama at Birmingham Division of Hematology and Oncology
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Geling Li
The University of Alabama at Birmingham Department of Pathology
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Elizabeth Beierle
The University of Alabama at Birmingham Department of Surgery
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Elizabeth Alva
The University of Alabama at Birmingham Division of Hematology and Oncology
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Abstract

Neuroblastoma is the most common extracranial solid tumor in children. Approximately half of the patients with Stage MS disease have tumor regression, but 10-15% will have progression of disease. BRAF mutations are common in some cancers, such as melanoma and pediatric astrocytoma, but are rare in pediatric extracranial solid tumors, including neuroblastoma. Here we report the case of an infant with Stage MS neuroblastoma with a rare BRAF V600E mutation and subsequent progression to Stage M disease.