Epigenetic regulation in epilepsy: a novel diagnostic and therapeutic
strategy for epilepsy
Abstract
Epilepsy is a common neurological disorder in which excessive and
abnormal neuronal discharges can be observed and is characterized by
recurrent seizures. The epileptogenesis is usually involved in
neuropathological processes such as ion channel dysfunction, neuronal
injury, inflammatory response, synaptic plasticity, glial cell
proliferation and mossin fibrosis, currently the pathogenesis of
epilepsy is not yet completely understood. A growing body of studies
have shown that epigenetic regulation, such as histone modifications,
DNA methylation, noncoding RNAs (ncRNAs), and restrictive element-1
silencing transcription factor/neuron-restrictive silencing factor
(REST/NRSF) are also involved in epilepsy. However, the functional roles
of epigenetics in pathogenesis and treatment of epilepsy are still to be
explored. Therefore, in this review, we will summarize latest advances
concerning the mechanisms of epigenetic regulation in epilepsy, which
provide novel insight into therapy and biomarkers for epilepsy.