Modified Intelligent Magnetic Nano particles as A Treatment for SARS
Corona Virus Type 2 In Silico
Abstract
The pandemic situation of the new corona virus (SARS-COV-2) forces drug
designers to formulate a new intelligent drug for this disease effective
to treat all mutations of the virus. One way to control all mutations of
virus is inhibition of spike protein (binding with Angiotensin
converting enzyme 2 (ACE-2)) duo to inhibit the viral entry. Viral entry
is the first step for virus to start infection. In this work the
interactions of SARS-COV-2 spike protein and ACE-2 are evaluated
Insilico by docking process and four different Ligands are estimated to
simulate those interactions, so as to avoid bindings with ACE-2 needed
for viral entry in reality. All Ligand – receptor interactions are
considered. Results approves the suggested Ligands in this work, have
definite inhibitory effect on SARS-COV-2 spike protein based on the
interactions which they make with receptor binding domain (RBD). Docking
process are done repeatedly to assure conclusions.