REAL-WORLD IMPLEMENTATION OF NORTH AMERICAN AND SIOP STRATEGIES FOR THE
TREATMENT OF WILMS TUMOR IN URUGUAY
Abstract
We performed an audit from 1995 to 2020 of patients with Wilms tumor in
a referral center in Uruguay. Treatment included North American (NA)
strategies (n=23) up to 2004 followed by SIOP strategy (n=35) thereafter
(stage I-II=28, III=7, IV=14 and V=9). Delay in local radiotherapy was
noted (median of 21 days after surgery). There was no toxic or surgical
death or abandonment. Five-year pOS was 0.72 and 0.92 for the NA and
SIOP respectively. Results favored the SIOP strategy with no unexpected
toxicities and high treatment compliance in both strategies. Timely
implementation of radiotherapy was challenging.