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Factors influencing sensitivity of a rapid influenza diagnostic test in a community-based population of kindergarten through 12th grade students: Wisconsin 2015-2020
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  • Cristalyne Bell,
  • Jennifer Birstler,
  • Maureen Goss,
  • Emily Temte,
  • Shari Barlow,
  • Guanhua Chen,
  • Amra Uzicanin,
  • Jonathan Temte
Cristalyne Bell
University of Wisconsin-Madison

Corresponding Author:[email protected]

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Jennifer Birstler
University of Wisconsin-Madison
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Maureen Goss
University of Wisconsin Madison
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Emily Temte
University of Wisconsin Madison Department of Family Medicine
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Shari Barlow
University of Wisconsin-Madison
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Guanhua Chen
University of Wisconsin-Madison
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Amra Uzicanin
Centers for Disease Control and Prevention
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Jonathan Temte
University of Wisconsin-Madison
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Abstract

Rapid influenza diagnostic tests (RIDTs) have variable sensitivity. In a community-based population of kindergarten through 12th grade (K-12) students, we assessed factors that may influence RIDT performance using 2,368 paired results from Sofia® Influenza A + B fluorescent immunoassay and reverse transcription polymerase chain reaction (RT-PCR). RIDT sensitivity and specificity were 76.1% (95% CI: 72.8—79.1) and 97.2% (96.2—97.9), respectively. Factors associated with sensitivity included runny nose (OR=3.0, p<0.001), nasal congestion (1.59, p=0.045), days from symptom onset (per day; 0.75; p<0.001), myalgia (0.61; p=0.014), age (per 5 years; 0.55; p=0.001), and detection of another virus (0.50; p=0.043). Understanding these factors can aid in interpreting negative results.
25 Sep 2022Submitted to Influenza and other respiratory viruses
26 Sep 2022Submission Checks Completed
26 Sep 2022Assigned to Editor
05 Oct 2022Editorial Decision: Revise Minor
06 Oct 20221st Revision Received
13 Oct 2022Submission Checks Completed
13 Oct 2022Assigned to Editor
13 Oct 2022Editorial Decision: Accept