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Paramedullary plasmacytoma originating from the first cervical vertebra (C1) in an 8-month-old warmblood weanling with tetraparesis: Clinical and pathological findings
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  • Vivien Schiffbauer,
  • Anna Pelli,
  • Simone Della Tommasa,
  • Reiner Ulrich,
  • Anja Reinert,
  • Kerstin Gerlach,
  • Iris Voelker
Vivien Schiffbauer
Leipzig University

Corresponding Author:[email protected]

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Anna Pelli
Leipzig University
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Simone Della Tommasa
University of Leipzig Faculty of Veterinary Medicine
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Reiner Ulrich
Leipzig University
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Anja Reinert
Leipzig University
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Kerstin Gerlach
Leipzig University
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Iris Voelker
Leipzig University
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Abstract

To the authorsʼ knowledge there is only one report in the literature, dealing with paramedullary plasmacytomas in horses as so-called “break out lesions”, originating from the bone marrow of a vertebra and invading the epidural space (Drew and Greatorex 1974). Our case report describes the clinical and patho-morphological findings of such a case. The affected 8-month-old warmblood weanling colt exhibited acute tetraparesis thus, a spinal cord lesion in the cervical column was suspected. Computed tomography revealed osteolytic lesions in C1 and a heterogeneous mass within the respective segment of the vertebral canal. By means of patho-morphological examination, with the aid of transmission electron microscopy, a plasmacytoma was identified, that had grown out of the bone marrow of C1 into the epidural space, locally compressing the spinal cord. In tetraparetic, young horses traumatic spine cord injuries, cervical vertebral malformations and infectious diseases of the central nervous system represent common differentials. However bone-dissolving tumours such as paramedullary plasmacytomas should be considered as a further possible cause in the presence of severe neurological deficits.
14 Oct 2022Submitted to Equine Veterinary Education
14 Oct 2022Submission Checks Completed
14 Oct 2022Assigned to Editor
29 Oct 2022Reviewer(s) Assigned
27 Nov 2022Review(s) Completed, Editorial Evaluation Pending
04 Jan 2023Editorial Decision: Revise Minor
03 Apr 20231st Revision Received
11 Jul 2023Submission Checks Completed
11 Jul 2023Assigned to Editor
09 Oct 2023Reviewer(s) Assigned
20 Nov 2023Review(s) Completed, Editorial Evaluation Pending
24 Feb 20242nd Revision Received
26 Feb 2024Review(s) Completed, Editorial Evaluation Pending
09 May 20243rd Revision Received
09 May 2024Submission Checks Completed
09 May 2024Assigned to Editor
09 Jul 2024Editorial Decision: Revise Minor
21 Jul 20244th Revision Received
22 Jul 2024Submission Checks Completed
22 Jul 2024Assigned to Editor
23 Jul 2024Editorial Decision: Accept