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Difficult-to-treat Diabetes Insipidus in a Patient with Midline Defect: A Case Report
  • +2
  • Atena Seifi,
  • Arefeh Zahmatkesh,
  • Mahnaz Jamee,
  • Mahbubeh Mirzaee,
  • Masoumeh mohkam
Atena Seifi
Shahid Beheshti University of Medical Sciences

Corresponding Author:[email protected]

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Arefeh Zahmatkesh
Shahid Beheshti University of Medical Sciences
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Mahnaz Jamee
Shahid Beheshti University of Medical Sciences
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Mahbubeh Mirzaee
Shahid Beheshti University of Medical Sciences
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Masoumeh mohkam
Shahid Beheshti University of Medical Sciences
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Abstract

Holoprosencephaly (HPE) is a complex brain malformation resulting from incomplete cleavage of the prosencephalon, occurring between the 18th and 28th day of gestation. Endocrinologic dysfunctions such as diabetes insipidus (DI), hypothyroidism, and growth hormone deficiency are common in HPE and correlated with the degree of hypothalamic non-separation.

Peer review status:IN REVISION

03 Aug 2022Submitted to Clinical Case Reports
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31 Oct 2022Submission Checks Completed
31 Oct 2022Assigned to Editor
06 Nov 2022Reviewer(s) Assigned
27 Dec 2022Review(s) Completed, Editorial Evaluation Pending
12 Mar 2023Editorial Decision: Revise Minor