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Clinical utility of point of care glucose in the assessment of gestational diabetes: Prospective cohort study.
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  • Wiaam Al-Hasani,
  • Ruvini Ranasinghe,
  • Helen Rogers,
  • William Spanier,
  • Katie Spears,
  • Carol Gayle,
  • Lisa Long,
  • Georgios K Dimitriadis,
  • Katharine F Hunt ,
  • Royce P Vincent
Wiaam Al-Hasani
King's College Hospital NHS Foundation Trust

Corresponding Author:[email protected]

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Ruvini Ranasinghe
King's College Hospital NHS Foundation Trust
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Helen Rogers
King's College Hospital NHS Foundation Trust
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William Spanier
King's College Hospital NHS Foundation Trust
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Katie Spears
King's College Hospital NHS Foundation Trust
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Carol Gayle
King's College Hospital NHS Foundation Trust
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Lisa Long
Kings College Hospital
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Georgios K Dimitriadis
King's College Hospital NHS Foundation Trust
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Katharine F Hunt
King's College Hospital NHS Foundation Trust
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Royce P Vincent
King's College Hospital NHS Foundation Trust
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Abstract

Objective: To assess the clinical utility of point of care (POC) capillary blood glucose (CBG) in the assessment of gestational diabetes (GDM) during oral glucose tolerance test (OGTT). Design: Prospective cohort study. Setting: Antenatal clinics at King’s Collage Hospital. Population: Women screening for GDM between March and June 2020. Methods: CBG was measured using POC-StatStrip® (Nova) and venous plasma glucose (VPG) was measured by Roche (Cobas 8000 c702) analyser. GDM was diagnosed based on NICE-2015 criteria. The two methods were compared statistically using Analyse-It (v 5.40.2) Main outcome measures: Diagnostic sensitivity, specificity, positive and negative predictive values (PPV and NPV) for POC-StatStrip® compared to reference laboratory method. Results: 230 women were included. The number and the percentage of women with glucose concentration above the GDM thresholds using POC-StatStrip® vs. Lab-VPG measurement was 15 (6.5%) vs. 8 (3.4%) at fasting and 105 (45%.6) vs. 72 (31.1%) at 2-hour respectively. Sensitivity and specificity for POC-StatStrip® were 88% and 97% at fasting and 97% and 79% at 2-hour respectively. However, the specificity and the NPV for POC-StatStrip® concentrations ≤5.0 mmol/L at fasting or <7.5mmol/L at 2-hour were 100% and the sensitivity and the PPV for concentration >9.5mmol/L at 2-hour was 100 %. Conclusion: In our cohort POC-CBG measurement cannot entirely replace laboratory method in OGTT, however, it can be used to rule out/rule in GDM when the glucose concentrations are ≤5.0mmol/L at fasting or <7.5/>9.5mmol/L at 2-hour. Funding: not applicable. Key Words: Gestational Diabetes Mellitus (GDM), point of care (POC).
24 Oct 2022Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
07 Nov 2022Submission Checks Completed
07 Nov 2022Assigned to Editor
07 Nov 2022Review(s) Completed, Editorial Evaluation Pending
25 Mar 2023Reviewer(s) Assigned
28 May 2023Editorial Decision: Revise Major
06 Jul 20231st Revision Received
11 Jul 2023Submission Checks Completed
11 Jul 2023Assigned to Editor
11 Jul 2023Review(s) Completed, Editorial Evaluation Pending
08 Aug 2023Editorial Decision: Revise Major
08 Aug 20232nd Revision Received
08 Aug 2023Assigned to Editor
08 Aug 2023Submission Checks Completed
08 Aug 2023Review(s) Completed, Editorial Evaluation Pending
30 Aug 2023Editorial Decision: Revise Major
17 Feb 20243rd Revision Received
20 Feb 2024Review(s) Completed, Editorial Evaluation Pending
03 Mar 2024Editorial Decision: Accept