Efficacy of cell-culture derived Influenza vaccines for children: A
systematic review and meta-analysis
Abstract
Objectives: To determine the efficacy of cell culture based
influenza vaccines in children. Methods: Embase, PubMed,
Cochrane and clinical trials were searched.14 randomised controlled
trials in children were selected. The current systematic review was done
as per the PRISMA guidelines. The pooled estimate of seroconversion and
GMT rate was calculated as mean difference. Data was analysed using the
Cochrane Collaboration Review Manager Version software. Risk of bias was
done as per Cochrane risk of bias tool. The quality of evidence was
adjudged using Grading of Recommendations, Assessment, Development, and
Evaluation (GRADE) using the Grade pro software. Results:
Significant results for efficacy were reported for half dose MF59
influenza vaccine control group for GMT at day 1 with a mean difference
of 0.78, 95%CI, 0.50 to 1.07, p<0.00001 as compared to full
dose MF59 influenza vaccine experimental group .No significant results
were reported in half dose MF59 influenza vaccine for GMT at Day 43(mean
difference 151.57,95% CI,-29.36 to 332.50 ,p=0.10). Significant results
were reported for seroconversion rate for half dose MF59 influenza
vaccine control group at day 22 with a mean difference of
17.92,95%CI,10.08 to 25.75,p<0.00001 as compared to half dose
MF59 influenza vaccine group at day 43 with a mean difference of
5.00,95%CI,-4.80 to 14.80,p=0.32 . Conclusion: The current
systematic review demonstrated that half dose cell derived influenza
vaccines was well tolerated and more immunogenic and resulted in high
seroconversion rate and Geometric Mean Titres rate in paediatric
population.