Introduction: A giant right ventricular myxoma with simultaneous pulmonary embolism during Transthoracic Echocardiographic examination is rare, hardly been reported in the literature. We present a case of a giant right ventricular myxoma with being separated into pulmonary thrombus simultaneously during process of Transthoracic Echocardiographic examination. Case presentation: An 18-year-old young man performed physical examination before college entrance examination. Transthoracic echocardiography (TTE) showed: a heterogeneous mass was found in the right ventricle. The patient suddenly felt the symptoms of chest pain and dyspnea during a transthoracic ultrasound examination, and TTE demonstrated the mass maybe a myxoma with being separated into pulmonary thrombus simultaneously. Electrocardiogram showed complete right bundle branch block. The young man underwent intracardiac repair immediately and was doing well. Discussion/Conclusion: Although myxoma of the right heart is common, complicating of pulmonary embolism during examination is rare especially. Early diagnosis of right heart myxoma complicated with pulmonary embolism provides an important basis for timely operation, and provides a guarantee for saving the life of patients.