AIM Neurodevelopmental and clinical problems in childhood often precede adult Schizophrenia Spectrum Disorders. We investigated if children attending a psychiatric clinic presented more cognitive and motor alterations if there was a family history of Schizophrenia Spectrum Disorder (FHR-SZ) diagnosis. We also searched if there was a relationship between clinical scores in CBCL Thought Problems and increased problems in motor and cognitive performance. METHODS Seventy-five children (aged 7 to 16; mean 12 y/o; 53% males) were recruited (45 reported FHR-SZ -seven of them first degree-). They completed the Wechsler Intelligence Scale for Children (WISC-V), Movement Assessment Battery for Children (MABC-2), social cognition from the Developmental NEuroPSYchological Assessment (NEPSY-II) and Conners Continuous Performance Test (CPT-3). Parents completed the Child Behaviour Checklist (CBCL) and Behaviour Rating Inventory of Executive Function (BRIEF-2). RESULTS A neurodevelopmental disorder was the primary diagnosis in 65% (mainly ADHD). Motor performance and emotion recognition were below expected by age, and IQ was average. No relevant differences in relation to family history were found. Patients with high scores in the CBCL Thought Problems subscale (n=38) were older, more often presented a diagnosis of combined ADHD, performed worse in Emotion Recognition, had Executive Function problems and clinical symptoms in subscales Anxious/Depressed, Withdrawal/Depressed and Attention problems. CONCLUSIONS In children attending a psychiatric clinic, CBCL Thought Problems subscale associates with more internalizing clinical problems, executive function, and social cognition difficulties. Larger samples and first-degree FHR-SZ probands are needed to delineate risk profiles.

As we speak, corollary discharge mechanisms suppress the auditory conscious perception of the self-generated voice in healthy subjects. This suppression has been associated with the attenuation of the auditory N1 component. To analyze this corollary discharge phenomenon (agency and ownership), we registered the Event-Related Potentials of forty-two healthy subjects. The N1 and P2 components were elicited by spoken vowels (talk condition; agency), by played-back vowels recorded with their own voice (listen-self condition; ownership), and by played-back vowels recorded with an external voice (listen-other condition). The N1 amplitude elicited by the talk condition was smaller compared to the listen-self and listen-other conditions. There were no amplitude differences in N1 between listen-self and listen-other conditions. The P2 component did not show differences between conditions. Additionally, a peak latency analysis of N1 and P2 components between the three conditions showed no differences. These findings corroborate previous results showing that the corollary discharge mechanisms dampen sensory responses to self-generated speech (agency experience), and provide new neurophysiological evidence about the similarities in the processing of played-back vowels with our own voice (ownership experience) and with an external voice.

As we speak, corollary discharge mechanisms suppress the auditory cortical response to the sensory perception of the self-generated voice in healthy subjects. This suppression has been associated with the attenuation of the auditory N1 component. To analyze this corollary discharge phenomenon (agency and ownership), we registered the Event-Related Potentials (ERPs) of thirty-five healthy subjects. The N1 and P2 components were elicited by spoken vowels (talk condition; agency), by played-back vowels recorded with their own voice (listen-self condition; ownership), and by played-back vowels recorded with an external voice (listen-other condition). The N1 amplitude elicited by the talk condition was smaller compared to the listen-self and listen-other conditions. There were no amplitude differences in N1 between listen-self and listen-other conditions. The P2 component did not show differences between conditions. Additionally, a peak latency analysis of N1 and P2 components between the three conditions showed no differences. These findings corroborate previous results showing that the corollary discharge mechanisms dampen sensory responses to self-generated speech (agency experience), and also provide new neurophysiological evidence about the similarities in the processing of played-back vowels with our own voice (ownership experience) and with an external voice.