Novel therapeutic approaches to target neurodegeneration
- Alerie Guzman de la Fuente,
- Silvia Pelucchi,
- Jerome Mertens,
- Mónica Di Luca,
- Daniela Mauceri,
- Elena Marcello
Alerie Guzman de la Fuente
Instituto de Investigación Sanitaria y Biomédica de Alicante
Author ProfileSilvia Pelucchi
Leopold Franzens Universität für Innsbruck
Author ProfileJerome Mertens
Leopold Franzens Universität für Innsbruck
Author ProfileAbstract
Ageing is the main risk factor common to most primary neurodegenerative
disorders. Indeed, age-related brain alterations have been long
considered to predispose to neurodegeneration. Although protein
misfolding and the accumulation of toxic protein aggregates have been
contemplated as causative events in neurodegeneration, several
biological pathways affected by brain ageing are also contributing to
pathogenesis. Here, we discuss the evidence showing the involvement of
the mechanisms controlling neuronal structure, gene expression,
autophagy, cell metabolism, and neuroinflammation in the onset and
progression of neurodegenerative disorders. Furthermore, we review the
therapeutic strategies currently under development or as future
approaches designed to normalize these pathways, which may then boost
brain resilience to cope with toxic protein species. Therefore, in
addition to therapies targeting the insoluble protein aggregates
specifically associated with each neurodegenerative disorder, these
novel pharmacological approaches may be part of combined therapies
designed to rescue brain function.21 Dec 2022Submitted to British Journal of Pharmacology 21 Dec 2022Submission Checks Completed
21 Dec 2022Assigned to Editor
22 Dec 2022Reviewer(s) Assigned
24 Jan 2023Review(s) Completed, Editorial Evaluation Pending
25 Jan 2023Editorial Decision: Revise Minor
26 Feb 20231st Revision Received
27 Feb 2023Submission Checks Completed
27 Feb 2023Assigned to Editor
08 Mar 2023Reviewer(s) Assigned
15 Mar 2023Review(s) Completed, Editorial Evaluation Pending
17 Mar 2023Editorial Decision: Accept