Abstract
The innate immune response plays an important role in the pathological
process of ischemic stroke. Increasing evidence suggests that the
inflammatory response triggered by the innate immune system hinders
neurological and behavioral recovery after stroke. The perception of
abnormal DNA and its downstream effects are an important part of the
innate immune system. The abnormal DNA is the major inducing factor for
innate immune response and is sensed by a series of DNA sensors. In this
review, we discussed the multiple roles of DNA sensing in the
pathological process of ischemic stroke, with a special focus on DNA
sensors Toll-like receptor 9 (TLR9), absent in melanoma 2 (AIM2) and
cyclic GMP-AMP synthase (cGAS).