Essential Site Maintenance: Authorea-powered sites will be updated circa 15:00-17:00 Eastern on Tuesday 5 November.
There should be no interruption to normal services, but please contact us at [email protected] in case you face any issues.

loading page

Cardiopulmonary Exercise Testing Among Adolescents with Obesity
  • +6
  • Joanna E. Nelson,
  • Kimberly M. Sanchez,
  • Yujing Yao,
  • Zhezhen Jin,
  • Jeffrey L. Zitsman,
  • Meyer Kattan,
  • Robert P. Garofano,
  • Aimee M. Layton,
  • Aliva De
Joanna E. Nelson
Columbia University Irving Medical Center

Corresponding Author:[email protected]

Author Profile
Kimberly M. Sanchez
Columbia University Irving Medical Center
Author Profile
Yujing Yao
Columbia University Department of Biostatistics
Author Profile
Zhezhen Jin
Columbia University Department of Biostatistics
Author Profile
Jeffrey L. Zitsman
Columbia University Irving Medical Center
Author Profile
Meyer Kattan
Columbia University Irving Medical Center
Author Profile
Robert P. Garofano
Columbia University Irving Medical Center
Author Profile
Aimee M. Layton
Columbia University Irving Medical Center
Author Profile
Aliva De
Columbia University Irving Medical Center
Author Profile

Abstract

OBJECTIVE: Cardiopulmonary exercise testing (CPET) is used prior to bariatric surgery in adolescents with obesity to assess surgical risk factors. Lack of normative equations for peak oxygen consumption (pVO2) for this population limits CPET interpretation. We aimed to use lean body weight (LBW) to predict pVO 2 and developed novel predictive equations for use in this population. METHODS: 446 participants with obesity ages 9-20 underwent CPET prior to bariatric surgery from January 1, 2006 to December 31, 2019. Bioelectrical impedance analysis helped calculate LBW. Achieving peak heart rate > 90% predicted and RER of >1.1 were considered satisfactory effort. RESULTS: 107 CPET studies (29%) were satisfactory. Mean weight was 127 ± 21 kg, and BF% 49.7 ± 6.8, and LBW 63 ± 10, kg. Mean pVO 2 was 22.2 ± 3.2 mL/kg/min. The mean pVO 2 using LBW was 44.8 ± 8.7 mL/kg/min. Total body weight (TBW) estimated pVO 2 to be 50.7 ± 7.0 % predicted[(1)](#ref-0001), while LBW estimated it at 102.3 ± 17.6 % predicted. Linear regression yielded reference equations pVO 2=1571.6+12.2*TBW (males) and pVO2=1301.8+10.6*TBW (females). CONCLUSION: When pVO 2 is corrected for LBW, adolescents with obesity demonstrate normal pVO 2. A novel set of equations were developed to predict absolute pVO 2 using TBW.