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Persulfate promoted carbamoylation of N-arylacrylamides with 4-carbamoyl-Hantzsch esters under metal-free conditions
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  • Qi Jing,
  • Jing Sun,
  • Jing-Yun Wang,
  • Mingdong Zhou
Qi Jing
Shenyang University of Chemical Technology
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Jing Sun
Liaoning University of Petroleum and Chemical Technology
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Jing-Yun Wang
Shenyang University of Chemical Technology
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Mingdong Zhou
Shenyang University of Chemical Technology

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Abstract

4-Carbamoyl-Hantzsch esters were used as carbamoyl radical precursors for oxidative carbamoylation of N-arylacrylamides in the presence of inexpensive persulfates. This protocol can be applied for a broad range of substrates with various functional groups, whereas a variety of 3,3-disubstituted oxindoles were obtained in good yields via an intermolecular addition/cyclization process.