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Improved monoclonal antibody neutralization for Omicron sublineages BA.2.75, BF.7 and BQ.1
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  • Krishna Khairnar,
  • Ekant Tamboli,
  • Lekha Salsekar,
  • Shefali Rahangdale
Krishna Khairnar
CSIR-National Environmental Engineering Research Institute

Corresponding Author:[email protected]

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Ekant Tamboli
CSIR-National Environmental Engineering Research Institute
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Lekha Salsekar
CSIR-National Environmental Engineering Research Institute
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Shefali Rahangdale
CSIR-National Environmental Engineering Research Institute
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Abstract

The mortality rate due to COVID-19 in immunocompromised cases is considerably high. Monoclonal antibody (mAb) therapy is essential in managing SARS-CoV-2 infection, especially in immunocompromised cases. The mutation in the spike protein RBD region of the SARS-CoV-2 leads to the substitution of amino acids resulting in an altered ACE2 binding affinity. The mAbs must be tested in-vitro using standard neutralisation assays designed against emerging SARS-CoV-2 variants to estimate the mAb therapy efficacy. Based on already available data on the mAb efficacy for known SARS-CoV-2 variants, it is plausible to draw inferences for other closely related SARS-CoV-2 variants in circulation owing to the similar spike protein RBD amino acid sequence. In this article, we have attempted to analyse the data of mAb efficacy tested against SARS-CoV-2 variants and extrapolate on other emerging omicron sublineages like BA.2.75, BF.7 and BQ.1.