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The seroepidemiology of measles in Xi'an, China
  • +13
  • Chunfu Zheng,
  • Yan Li,
  • Yao Bai,
  • Siruo Zhang,
  • Tao Lu,
  • Lei Han,
  • Yuewen Han,
  • Yujie Yang,
  • Zerun Xue,
  • Lingling Kou,
  • Pengbo Yu,
  • Jinbo Zhai,
  • Yanli Xi,
  • Mengzhou Xue,
  • Rui Wu,
  • Chaofeng Ma
Chunfu Zheng
University of Calgary
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Yan Li
Xi'an Center for Disease Control and Prevention
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Yao Bai
Xi'an Center for Disease Control and Prevention
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Siruo Zhang
Xi'an Jiaotong University Department of Pathogenic Biology and Immunology
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Tao Lu
Xi'an Center for Disease Control and Prevention
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Lei Han
Xi'an Jiaotong University Department of Pathogenic Biology and Immunology
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Yuewen Han
Xi'an Center for Disease Control and Prevention
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Yujie Yang
Xi'an Center for Disease Control and Prevention
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Zerun Xue
Xi'an Center for Disease Control and Prevention
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Lingling Kou
Xi'an Center for Disease Control and Prevention
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Pengbo Yu
Shaanxi Provincial Center for Disease Control and Prevention
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Jinbo Zhai
Universities of Inner Mongolia Autonomous Region
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Yanli Xi
Xi'an Center for Disease Control and Prevention
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Mengzhou Xue
The Second Affiliated Hospital of Zhengzhou University
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Rui Wu
Xi'an Center for Disease Control and Prevention
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Chaofeng Ma
Xi'an Center for Disease Control and Prevention

Corresponding Author:[email protected]

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Abstract

The number of measles cases reported worldwide has increased in recent years, and in 2015, there was a measles outbreak in Xi’an, China. However, the epidemiology of measles and the seroepidemiology of healthy people after 2015 have not been fully understood. We collected fingertip blood samples from healthy people around each suspected measles case in Xi’an in 2016-2018 and tested IgG using ELISA. Eighty measles cases were reported in Xi’an in 2016–2018, with an average annual incidence of 0.29 per 100,000 persons. Children aged ≤ 5 years and adults aged 25-29 accounted for a large proportion of measles cases. More than half of the cases in the 0-year group were under 8 months. A total of 5476 blood samples from healthy people were collected. Apart from 1-4 years and over 40, other age groups’ seroprevalence was 93%. Our findings suggest that the first vaccine shot should be administered at 6 months or earlier, the second at 12 months, and the third at 10 years, and couples prepared for [pregnancy](javascript:showjdsw(’showlj_1’,’lj_1’)) should be vaccinated with another dose. The findings may provide novel insights into measles elimination.