To date (2/5/2023), nearly three years after the official declaration of the COVID-19 pandemic, a total of 754, 018, 841 cases and 6,817,478 deaths have been officially reported to the world health organization (WHO) ([https://covid19.who.int/](https://covid19.who.int/)). During this time, the global populace has witnessed the devastating effects of this pandemic, which can undoubtedly be considered the sanitary event of the century. In my opinion, understanding the mechanisms associated with the evolution of SARS-CoV-2 is the most important aspect of understanding the course of this pandemic. In this respect, the millions of viral sequences generated during the pandemic (1) have significantly aided in the tracking of the pandemic, resulting in the identification of multiple variants of concern.