Urban expansion and the increasing frequency and intensity of extreme precipitation events bring new challenges to stormwater collection systems. One underrecognized issue is the occurence of transient flow conditions that lead to adverse multiphase flow interactions (AMFI): essentially, the formation, collapse, and uncontrolled release of air pockets within stormwater system flows. While the fundamental physics of AMFI have been evaluated in laboratory experiments and idealized modeling studies, much less is known about their development in real or simulated stormwater networks, and about the roles played by rainfall and network properties. A necessary precursor to AMFI is the development of pressurized flow conditions within a network. The goal of this study is to understand how spatiotemporal rainfall variability affects the occurrence of pressurized conditions in a stormwater drainage network in the Richmond district of San Francisco, California. High-resolution bias-corrected radar rainfall fields for 24 recent storms were used as the independent variable of EPA-SWMM simulations. Model analyses indicate that the incidence of pressurized flow increases with storm intensity, and is more sensitive to rainfall temporal variability than spatial variability.