Background: Longitudinal strain is helpful in discriminating between cardiac amyloidosis and other causes of left ventricle hypertrophy. We aimed to compare left atrial strain between light chain cardiac amyloidosis (AL-CA) and hypertensive heart disease (HHD). Methods: Echocardiography was performed at 21 consecutive AL-CA patients, 56 HHD patients and 21 controls who were enrolled in the current study between April 2018 and January 2021. Echo PAC workstation was employed to analyze LA strain of all the participants. Standard echocardiographic parameters and LA strain parameters were compared between AL-CA and HHD patients. ROC curves were employed to assess the discriminating ability of LA strain. Results: LASr and LASct were significantly lower (21.03 vs 26.17, P =0.009, and 12.11 vs 15.51, P=0.009, respectively) in AL-CA group than those in HHD group, whereas LAScd and SD-TPS were similar between the two groups (P=0.17 and P=0.27, respectively). The cutoff points of LASr and LASct for discriminating between AL-CA and HHD were 19.53% and 11.34%, respectively. Conclusions: AL-CA patients had marked reductions in LASr and LASct. LA strain had additional value in differentiating AL-CA from HHD patients.