Abstract
Pathogenic variants in the Surfactant Protein C gene ( SFTPC)
result in fibrotic childhood interstitial lung disease (chILD). We
previously reported three children with SFTPC pathogenic variants
with respiratory failure who were supported by chronic invasive
ventilation via tracheostomy as an alternative to lung transplantation
or comfort care [(1)](#ref-0001). We present two children with
SFTPC pathogenic variants treated with non-invasive ventilation
(NIV) (Figure 1).