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Pediatric Systemic Juvenile Idiopathic Arthritis related Lung Disease: Description of clinical cohort and review of management.
  • +2
  • Jade Tam-Williams,
  • Chandra Swanson,
  • Ashley Cooper,
  • Maria Ibarra,
  • Erin Khan
Jade Tam-Williams
Children's Mercy Research Institute

Corresponding Author:[email protected]

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Chandra Swanson
Children's Mercy Research Institute
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Ashley Cooper
Children's Mercy Research Institute
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Maria Ibarra
Children's Mercy Research Institute
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Erin Khan
Children's Mercy Research Institute
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Abstract

Beginning in the early 2010s, an increased incidence of interstitial lung disease in systemic juvenile idiopathic arthritis (sJIA-LD) in pediatric patients has been identified. Despite the increase in prevalence of sJIA-LD, little is known about this disease process and effective therapeutic management. In this single-center, retrospective case series of 9 patients, we analyze demographic, clinical, radiographic, and laboratory data to corroborate common clinical characteristics and describe an approach for diagnosis and monitoring of interstitial lung disease in children with sJIA. Our results were similar to other described cases of sJIA-LD as patients in our cohort were more likely to be younger, have a history of macrophage activation syndrome and prior use of biologic therapies. In contrast to prior studies, they did not present with lymphadenopathy and hepatosplenomegaly. We discuss our management of this rare disease process. More research is necessary to understand the increased incidence and treatment of sJIA-LD in pediatric population.
18 May 2023Submitted to Pediatric Pulmonology
18 May 2023Submission Checks Completed
18 May 2023Assigned to Editor
18 May 2023Review(s) Completed, Editorial Evaluation Pending
29 May 2023Reviewer(s) Assigned
30 Jun 2023Editorial Decision: Revise Major
18 Sep 20231st Revision Received
27 Sep 2023Submission Checks Completed
27 Sep 2023Assigned to Editor
27 Sep 2023Review(s) Completed, Editorial Evaluation Pending
27 Sep 2023Reviewer(s) Assigned
19 Oct 2023Editorial Decision: Revise Minor
10 Nov 20232nd Revision Received
14 Nov 2023Submission Checks Completed
14 Nov 2023Assigned to Editor
14 Nov 2023Review(s) Completed, Editorial Evaluation Pending
14 Nov 2023Reviewer(s) Assigned