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Frequency and burden of disease for SARS-CoV-2 and other viral respiratory tract infections in children under the age of 2 months
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  • François Dubos,
  • Marie Latouche,
  • Mahdi Ouafi,
  • Ilka Engelmann,
  • Adrien Becquart,
  • Enagnon Kazali Alidjinou,
  • Ayoub Mitha
François Dubos
Centre Hospitalier Universitaire de Lille

Corresponding Author:[email protected]

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Marie Latouche
Centre Hospitalier Universitaire de Lille
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Mahdi Ouafi
Universite de Lille Faculte de Medecine
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Ilka Engelmann
Universite de Lille Faculte de Medecine
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Adrien Becquart
Universite de Lille Faculte de Medecine
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Enagnon Kazali Alidjinou
Universite de Lille Faculte de Medecine
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Ayoub Mitha
Centre Hospitalier Universitaire de Lille
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Abstract

Objective: To evaluate the frequency and burden of disease of SARS-CoV-2 and other respiratory viruses in children under the age of 2 months. Methods: A retrospective, cross-sectional, single-center study was conducted between March 2021, and February 2022. All children under the age of 2 months and tested for SARS-CoV-2 were included. The frequency of SARS-CoV-2, of other respiratory viruses and the burden of disease caused by SARS-CoV-2 and other respiratory viruses were evaluated. Results: 727 children with an RT-PCR test for SARS-CoV-2 were included (mean age: 0.9 months (±0.6); boys: 57%); 514 (71%) in the emergency room and 213 (29%) in hospital. Among them, 62 (8.5%) had a positive RT-PCR test for SARS-CoV-2, more often in the Omicron period (23%) than in the Alpha period (4%). Of the 565 (78%) with a multiplex RT-PCR test for other viruses, 325 (58%) were positive. Children with a positive SARS-CoV-2 were less likely to have required respiratory support (p=.001), enteral nutrition (p=.03), or intensive care admission (p=.01) and had a shorter hospital stay than children with other respiratory viruses (5d vs. 7d, p=.007). Conclusion: In this young population of children, SARS-CoV-2 infection was less frequent and less severe than other viral respiratory infections.
09 Apr 2023Submitted to Pediatric Pulmonology
11 Apr 2023Assigned to Editor
11 Apr 2023Submission Checks Completed
11 Apr 2023Review(s) Completed, Editorial Evaluation Pending
23 Apr 2023Reviewer(s) Assigned
03 Jun 2023Editorial Decision: Revise Major
26 Jun 20231st Revision Received
07 Jul 2023Submission Checks Completed
07 Jul 2023Review(s) Completed, Editorial Evaluation Pending
07 Jul 2023Assigned to Editor
07 Jul 2023Reviewer(s) Assigned
27 Aug 2023Editorial Decision: Revise Minor
07 Sep 20232nd Revision Received
08 Sep 2023Submission Checks Completed
08 Sep 2023Review(s) Completed, Editorial Evaluation Pending
08 Sep 2023Assigned to Editor
08 Sep 2023Reviewer(s) Assigned
20 Sep 2023Editorial Decision: Accept