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CLA + memory T cells in atopic dermatitis
  • +5
  • Luis Santamaria-Babí ,
  • Lídia Sans-de San Nicolàs,
  • Tali Czarnowicki,
  • Mübeccel Akdis,
  • Ramon Maria Pujol,
  • Daniel Lozano-Ojalvo,
  • Donald Leung,
  • Emma Guttman-Yassky
Luis Santamaria-Babí
Universitat de Barcelona Departament de Biologia Cellular Fisiologia i Immunologia

Corresponding Author:[email protected]

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Lídia Sans-de San Nicolàs
Universitat de Barcelona Departament de Biologia Cellular Fisiologia i Immunologia
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Tali Czarnowicki
Shaare Zedek City Center Campus
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Mübeccel Akdis
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Ramon Maria Pujol
Institut Hospital del Mar d'Investigacions Mediques
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Daniel Lozano-Ojalvo
Icahn School of Medicine at Mount Sinai Department of Medicine
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Donald Leung
University of Colorado Anschutz Medical Campus Department of Pediatrics
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Emma Guttman-Yassky
Icahn School of Medicine at Mount Sinai Department of Medicine
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Abstract

CLA + memory T cells constitute a small subset of human memory T cells. Circulating skin-homing T cells participate in several aspects of atopic dermatitis, such as Staphylococcus aureus involvement in inflammation, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are related to CLA + T cell response in patients. The function of CLA + T cells is closely related to the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
03 Apr 2023Submitted to Allergy
03 Apr 2023Submission Checks Completed
03 Apr 2023Assigned to Editor
03 Apr 2023Review(s) Completed, Editorial Evaluation Pending
08 Apr 2023Reviewer(s) Assigned
07 May 2023Editorial Decision: Revise Minor
08 Jun 20231st Revision Received
08 Jun 2023Submission Checks Completed
08 Jun 2023Assigned to Editor
14 Jun 2023Reviewer(s) Assigned
27 Jun 2023Review(s) Completed, Editorial Evaluation Pending
02 Jul 2023Editorial Decision: Accept