Abstract
CLA + memory T cells constitute a small subset of
human memory T cells. Circulating skin-homing T cells participate in
several aspects of atopic dermatitis, such as Staphylococcus
aureus involvement in inflammation, the abnormal Th2 immune response,
biomarkers, clinical aspects of the patients, pruritus, and the
mechanism of action of targeted therapies. Superantigens, IL-13, IL-31,
pruritus, CCL17 and early effects on dupilumab-treated patients have in
common that they are related to CLA + T cell response
in patients. The function of CLA + T cells is closely
related to the role of T cells belonging to the skin-associated lymphoid
tissue and could be a reason why they reflect different mechanisms of
atopic dermatitis. The goal of this review is to gather all this
translational information of atopic dermatitis pathology.