Catheter ablation represents nowadays a cornerstone for the treatment of atrial fibrillation. However, the benefit-risk ratio of this procedure still needs to be significantly improved. Many strategies have been proposed for this goal. Increased experience of operators and technological advances appear to be crucial points. Very important in this scenario is improving patients selection for ablation, as well. The blooming of artificial intelligence and machine learning represents a solid promise in many fields of medicine. Even in the field of atrial fibrillation cure they could prove to have a strong impact. Further prospective studies will surely help to define the real role of these techonologies in the treatment of atrial fibrillation.