1. IntroductionChikungunya fever is a persistent joint pain disease caused by mosquito-borne arboviruses: chikungunya virus (CHIKV). In Chikungunya fever, inflammatory cytokines such as IL-6, Il-17, IL-22, and IL-23 ［1,2］ are involved in chronic joint pain, but there are no reports on whether IL-36 is specified as a cause of joint pain. This case study compares the changes in IL-36α and β levels during infected chikungunya fever and the recovery. This article highlights the relationship between chikungunya fever and IL-36.