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Risk of stillbirth after a previous caesarean delivery: A Swedish nationwide cohort study
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  • Sukainah Al Khalaf Y,
  • Alexander Heazell,
  • Marius Kublickas,
  • Karolina Kublickiene,
  • Ali Khashan
Sukainah Al Khalaf Y
University College Cork School of Public Health

Corresponding Author:[email protected]

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Alexander Heazell
The University of Manchester Faculty of Biology Medicine and Health
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Marius Kublickas
Karolinska Universitetssjukhuset Kvinnokliniken
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Karolina Kublickiene
Karolinska Institutet Institutionen for klinisk vetenskap intervention och teknik
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Ali Khashan
University College Cork School of Public Health
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Abstract

Objectives To investigate the risk of stillbirth in relation to; 1) a previous CD compared to those following a vaginal birth (VB); and 2) vaginal birth after caesarean (VBAC) compared to a repeat CD. Design Population-based cohort study. Setting The Swedish Medical Birth registry Population Women with their first and second singletons between 1982 and 2012. Methods Multivariable logistic regression models were performed to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) of the association between CD in the first pregnancy and stillbirth in the second pregnancy and the association between VBAC and stillbirth. Sub-group analyses were performed by types of CD and timing of stillbirth (antepartum and intrapartum). Main outcome measures Stillbirth (antepartum and intrapartum fetal death). Results Of the 1,771,700 singleton births from 885,850 women,117,114 (13.2%) women had a CD in the first pregnancy, and 51,755 had VBAC in the second pregnancy. We found a 37% increased odds of stillbirth (aOR:1.37 [95% CI, 1.23–1.52]) in women with a previous CD compared to VB. The odds of intrapartum stillbirth was higher in previous pre-labour CD group (aOR:2.72 [95% CI, 1.51–4.91]) than the previous in-labour CD group (aOR:1.35 [95% CI, 0.76–2.40,]), although not statistically significant in the latter case. No increased odds was found for intrapartum stillbirth in women who had VBAC (aOR:0.99 [95% CI, 0.48–2.06]) compared to women who had a repeat CD, whereas women with antepartum stillbirth were more likely to have a VBAC (aOR:4.49 [95% CI, 3.55–5.67]). Conclusions This study confirms that a CD is associated with an increased risk of subsequent stillbirth, with a greater risk among pre-labour CD. This association is not solely mediated by increases in intrapartum asphyxia, uterine rupture or attempted VBAC. Further research is needed to understand this association, but these findings might help health care providers to reach optimal decisions regarding mode of birth, particularly when CD is unnecessary.
07 Apr 2023Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
08 Apr 2023Submission Checks Completed
08 Apr 2023Assigned to Editor
08 Apr 2023Review(s) Completed, Editorial Evaluation Pending
12 Apr 2023Reviewer(s) Assigned
18 Nov 2023Editorial Decision: Revise Major