Science AMA Series: We are a team of scientists, including diabetes
specialist and dermatologists, trialling a new treatment for type 1
diabetes.
Abstract
This is a pilot study to begin examining whether ustekinumab, a drug
typically used for psoriasis, has the potential to reduce or eliminate
the need for insulin injections in people with recently diagnosed Type 1
diabetes. “As one of the first clinical trials to target the immune
cells that cause Type 1 diabetes, we are hopeful that this treatment
will be a step towards finding a way to stop or slow the destruction of
the body’s own insulin-producing cells.” Dr. Jan Dutz, Principal
Investigator We are here to answer questions about diabetes, what this
drug could mean for people with Type 1 diabetes, why we are looking at
repurposing what seems like an unrelated medication, and anything else
you’d like to ask us. http://www.bcdiabetes.ca/type1study/ Dr. Tom
Elliott: Since 1992, Dr. Elliott has been a faculty member at UBC, where
his current rank is Clinical Associate Professor. He was Co-Director of
Undergraduate Medical Education for the UBC Division of Endocrinology
from 1992 to 2012, and chaired the Endocrinology & Metabolism Society
of BC, the professional body representing all BC endocrinologists and
diabetes specialists, from 2008 to 2012. Also since 1992, Dr. Elliott
has been on the active medical staff at Vancouver General Hospital, as
well as conducting a busy private office practice in Endocrinology &
Diabetology. Dr. Elliott is Director of Clinical Trials at BC Diabetes.
He has authored more than 50 scientific papers and is actively engaged
in 15 ongoing research projects. Dr. Ashish Marwaha Dr. Ashish Marwaha
is a clinical pediatric academic who was appointed as a Radcliffe
Travelling Fellow of University College, Oxford to pursue a PhD, in
which he identified a novel subset of highly inflammatory immune cells
(Th17) were present in children with new-onset type 1 diabetes (T1D)
(Cutting Edge: Journal of Immunology, 2010). He has taken an active role
in obtaining funding, designing, setting-up and running the current
clinical trial of ustekinumab that will block the Th17 pathway in T1D.