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Xing Quan
Public Documents
1
Calcium iodide mediated coupling of complex fluorooligosaccharides to phenolic peptid...
Pei Liu
and 5 more
April 29, 2023
Besides serving as therapeutic agents and building blocks for glycoprotein synthesis, homogeneous synthetic glycopeptides also benefit understanding function of specific glycoform. However, the selectivity coupling of oligosaccharides to a given peptide remains challenging despite the fact that the synthesis of structure-defined complex oligosaccharides has been greatly facilitated by chemoenzymatic based approaches. Herein, a Ca2+-promoted glycosylation approach was developed to exclusively modify phenolic peptide using a panel of biologically important glycans.