Multimodal retinal imaging in leukemic retinopathy in children with
chronic myeloid leukemia
Abstract
Objective: To evaluate changes in multimodal retinal imaging of patients
with chronic myeloid leukemia. Methods: Observational case series study.
All patients underwent a complete ophthalmic examination and were imaged
with multimodal imaging before and after therapy for CML. Results: Mean
age at diagnosis was 15 years old. All patients were male. The retinal
findings at diagnosis were foveal infiltrates in 66.6%, retinal
infiltration in 66.6%, venous dilation and arterial tortuosity in
66.6%, retinal hemorrhages in 100%, pre-retinal hemorrhages 33.3%,
cotton-wool spots in 66.6%, Roth’s spots in 100%. Mean follow-up was
94.6 weeks (range 20-150 weeks). Regression of LR was completed after
100 days (range 56-170 days), and regression of macular infiltrates, at
day 19 (range 17-21 days). Conclusion: MRI can provide relevant
information when monitoring clinical response for systemic conditions
affecting the eyes. At first, foveal infiltrates tend to disappear once
the induction therapy has started. Retinal hemorrhages, vascular
dilation, retinal infiltrates, and cotton wool spots tend to gradually
disappear associated to the reduction of mature cells into the blood
stream and the achievement of a major molecular response (MMR) assessed
by TR-PCR.