Tropospheric O3 damage to plants significantly affects global vegetation productivity, yet accurately predicting this damage remains challenging. This study develops a parameterization to globally predict ozone damage by integrating a combination of factors: cumulative uptake of ozone (CUO), O3 concentration, stomatal conductance (Gs), and total exposure time. We compiled experimental data from over 200 peer-reviewed publications spanning 50 years, focusing on the responses of various crops and trees to chronic ozone exposure. Our analysis reveals that while CUO alone has a weak relationship with changes in photosynthesis and stomatal conductance under O3 stress, combining CUO with O3 concentration, Gs, and total exposure time significantly strengthens the predictive power. This combined approach was validated across diverse categories from experimental data, including plant types, tree age, exposure systems, types of control air, rooting environments, and ozone concentration bins. We found photosynthesis exhibited a weaker response relationship than stomatal conductance, indicative of underlying responses to O3 stress that could not be captured by the variables and methods used in this study. Our results underscore the complexity of predicting O3 damage and highlight the importance of synthesizing multiple predictors. Future research should incorporate other environmental stressors, e.g., heat, drought, and elevated CO2 levels, to enhance the accuracy of O3 damage models. This study provides a significant advancement in incorporating O3 damage parameterization for global crop and land surface modeling.