INTRODUCTION Pheochromocytoma, arising from the chromaffin cells of the adrenal medulla, can cause excessive catecholamines secretion and trigger pheochromocytoma crisis, characterized by high mortality rate up to 13%1. Pheochromocytoma crisis induced catecholaminergic cardiomyopathy may lead to multiple organ system damage or dysfunction, myocardial infarction, acute left ventricular failure, cardiogenic shock, and other fatal outcomes, commonly in undiagnosed or well-controlled pheochromocytoma2. Surgical resection is the primary treatment; however, the instability of perioperative hemodynamics poses a high risk of anesthesia and poses great challenges in treatment3. Currently, research on the diagnosis, treatment, and nursing care of such patients is mainly based on case reports. Veno-arterial extracorporeal membrane oxygenation (VA -ECMO) has been reported to stabilize circulation and extend the surgical window for patients with severe myocardial injury or circulatory failure4. In June 2021, we successfully treated a patient with pheochromocytoma presenting with cardiogenic shock as the first manifestation of multiple organ failure. This case report presents our experience in diagnosis, treatment, and nursing care of pheochromocytoma with various severe complications.