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Pan-Cancer Analysis Identifies CCDC51 as a Potential Biomarker for Liver Hepatocellular Carcinoma
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  • Shaoyi Wang,
  • peng chen,
  • zhang chen,
  • Xiaoyan Huang
Shaoyi Wang
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
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peng chen
YONGJIA PEOPLE'S HOSPITAL
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zhang chen
The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical University
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Xiaoyan Huang
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

Corresponding Author:[email protected]

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Abstract

Background: Coiled coil domain containing protein 51 (CCDC51), as the two transmembrane helical domains protein, little is known about the function of it in human cancer. Methods: TCGA, GEPIA, cBioPortal, GTEx, and TIMER were employed to analyze expression, immune cells infiltration, prognostic value, genetic alteration, cancer patients’ mutation burden, stem cell stability, and microsatellite instability of CCDC51 . Results: Decreased CCDC51 expression significantly related with poor overall survival (OS) of acute myeloid leukemia (LAML), adrenocortical carcinoma (ACC), glioma (GBMLGG), kidney chromophobe (KICH), liver hepatocellular carcinoma (LIHC), lung squamous cell carcinoma (LUSC), skin cutaneous melanoma (SKCM) and uveal melanoma (UVM), lung adenocarcinoma (LUAD), disease-specific survival (DSS) of ACC, GBMLGG, SKCM and UVM, and progression-free interval (PFI) of ACC, KICH and pancreatic adenocarcinoma, squamous cell carcinoma of the head and neck (HNSC). In human cancer, immune cell infiltration, and tumor microenvironment, CCDC51 expression is associated with MSI, RNA modifications, and diverse cancer drug sensitivity. There is potential for it to be an independent factor contributing to OS in LIHC. CCDC51 was an independent factor for LIHC prognosis in Cox regression and nomogram analysis. The results of the the Kyoto Encyclopedia of Genes and Gene Ontology and Genomes indicated that CCDC51 was involved in aminoacyl-tRNA biosynthesis, RNA transport, colorectal cancer, Wnt signaling pathway, mismatch repair, mitochondrion, pseudo uridine synthase activity, mRNA processing, mitochondrial matrix, regulation of mRNA stability, and mitochondrial inner membrane. Conclusion: Our research can provide new-insights for LIHC prognostic biomarkers of CCDC51.
02 Apr 2023Submitted to Cancer Reports
30 May 2023Submission Checks Completed
30 May 2023Assigned to Editor
30 May 2023Review(s) Completed, Editorial Evaluation Pending
05 Jun 2023Reviewer(s) Assigned
30 Jun 2023Editorial Decision: Revise Major
01 Aug 20231st Revision Received
02 Aug 2023Submission Checks Completed
02 Aug 2023Assigned to Editor
02 Aug 2023Review(s) Completed, Editorial Evaluation Pending
03 Aug 2023Reviewer(s) Assigned
29 Aug 2023Editorial Decision: Revise Major
17 Sep 20232nd Revision Received
29 Sep 2023Submission Checks Completed
29 Sep 2023Assigned to Editor
29 Sep 2023Review(s) Completed, Editorial Evaluation Pending
06 Oct 2023Reviewer(s) Assigned
06 Nov 2023Editorial Decision: Revise Minor
27 Feb 20243rd Revision Received
04 Mar 2024Submission Checks Completed
04 Mar 2024Assigned to Editor
04 Mar 2024Review(s) Completed, Editorial Evaluation Pending
06 Mar 2024Reviewer(s) Assigned
24 Mar 2024Editorial Decision: Accept