Primary Central Nervous System Anaplastic Large Cells Lymphoma in
children: case presentation and systematic review of literature
Abstract
Primary Central Nervous System Lymphoma is a rare extranodal non-Hodgkin
lymphoma, primarily arising in brain and spinal cord tissue,
leptomeninges and vitreoretinal eye. Pediatric PCNSLs are even rarer. We
describe the case of a boy presenting with seizures and a suspected
brain meningioma, but a final diagnosis of ALK+ Anaplastic Large Cell
Lymphoma. We conducted a qualitative systematic review following the
ENTREQ framework on pediatric cases of PCNSL, identifying only nine
cases of brain ALCL. Our work describes the high frequency of
misdiagnosis correlating with poor prognosis, and highlights the
importance of a multidisciplinary approach considering ALCL among
differential diagnosis.