Analysis of Clinical and Pathological Features of Omicron Variants of
SARS-CoV-2 associated Kidney Injury
Abstract
Kidney injury is common in patients with Coronavirus Disease-19
(COVID-19). In this study, 49 patients with Omicron associated kidney
injury were included, 38 of whomperformed renal biopsy. Patients were
divided into 2 groups: Group A for patients developing kidney injury
afterSARS-CoV-2 infection and Group B for patients with aggravated renal
insufficiency after SARS-CoV-2 infection. The clinical, pathological and
prognostic characteristicsof the patients and theirC3 levels were
observed.In our center, the clinical diagnoses of patients with COVID-19
associated kidney injury were mainly acute kidney injury(AKI), chronic
kidney disease(CKD) and nephrotic syndrome(NS); while the pathological
diagnoses were mainly IgA nephropathy(IgAN)、focal segmental
glomerulosclerosis(FSGS) and membranous nephritis(MN).80% of COVID-19
associated nephropathy (COVAN) patients had normal serum C3 complement
level, and a few patients had increased or decreased C3 level. In renal
tissue, C3 deposits were observed in 68.4% of patients.29% of patients
experienced deterioration of renal function after treatment, but no
patients developed to end-stage renal disease (ESRD). Among all of them,
one case presenting with thrombotic microangiopathy (TMA) had a more
severe renal pathological lesion and poorer prognosis. We observed
differences of clinical and pathological features of patients with
COVID-19associated kidney injury between races, regions and virus
variants. Asian patients with Omicron associated kidney injury have
milder kidney injury and a better renal prognosis.