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Analysis of Clinical and Pathological Features of Omicron Variants of SARS-CoV-2 associated Kidney Injury
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  • Xuejing Zhu,
  • Zhiwen Qi,
  • Shuguang Yuan,
  • Jinying Wei,
  • Shiyu Xia,
  • Yao Huang,
  • Xiaojun Chen,
  • Yachun Han,
  • Zheng Li,
  • Yang Xiao,
  • * FenghuaPeng,
  • Xiao Fu,
  • Lin Sun,
  • Hong Liu
Xuejing Zhu
The Second Xiangya Hospital of Central South University Department of Nephrology

Corresponding Author:[email protected]

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Zhiwen Qi
The Second Xiangya Hospital of Central South University Department of Nephrology
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Shuguang Yuan
The Second Xiangya Hospital of Central South University Department of Nephrology
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Jinying Wei
The Second Xiangya Hospital of Central South University Department of Nephrology
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Shiyu Xia
The Second Xiangya Hospital of Central South University Department of Nephrology
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Yao Huang
The Second Xiangya Hospital of Central South University Department of Nephrology
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Xiaojun Chen
The Second Xiangya Hospital of Central South University Department of Nephrology
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Yachun Han
The Second Xiangya Hospital of Central South University Department of Nephrology
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Zheng Li
The Second Xiangya Hospital of Central South University Department of Nephrology
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Yang Xiao
The Second Xiangya Hospital of Central South University National Clinical Research Center for Metabolic Diseases
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* FenghuaPeng
Second Xiangya Hospital Department of Kidney Transplantation
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Xiao Fu
The Second Xiangya Hospital of Central South University Department of Nephrology
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Lin Sun
The Second Xiangya Hospital of Central South University Department of Nephrology
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Hong Liu
The Second Xiangya Hospital of Central South University Department of Nephrology
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Abstract

Kidney injury is common in patients with Coronavirus Disease-19 (COVID-19). In this study, 49 patients with Omicron associated kidney injury were included, 38 of whomperformed renal biopsy. Patients were divided into 2 groups: Group A for patients developing kidney injury afterSARS-CoV-2 infection and Group B for patients with aggravated renal insufficiency after SARS-CoV-2 infection. The clinical, pathological and prognostic characteristicsof the patients and theirC3 levels were observed.In our center, the clinical diagnoses of patients with COVID-19 associated kidney injury were mainly acute kidney injury(AKI), chronic kidney disease(CKD) and nephrotic syndrome(NS); while the pathological diagnoses were mainly IgA nephropathy(IgAN)、focal segmental glomerulosclerosis(FSGS) and membranous nephritis(MN).80% of COVID-19 associated nephropathy (COVAN) patients had normal serum C3 complement level, and a few patients had increased or decreased C3 level. In renal tissue, C3 deposits were observed in 68.4% of patients.29% of patients experienced deterioration of renal function after treatment, but no patients developed to end-stage renal disease (ESRD). Among all of them, one case presenting with thrombotic microangiopathy (TMA) had a more severe renal pathological lesion and poorer prognosis. We observed differences of clinical and pathological features of patients with COVID-19associated kidney injury between races, regions and virus variants. Asian patients with Omicron associated kidney injury have milder kidney injury and a better renal prognosis.
22 Jun 2023Submitted to Journal of Medical Virology
22 Jun 2023Submission Checks Completed
22 Jun 2023Assigned to Editor
22 Jun 2023Review(s) Completed, Editorial Evaluation Pending
23 Jun 2023Reviewer(s) Assigned
27 Jul 2023Editorial Decision: Revise Major
25 Aug 20231st Revision Received
25 Aug 2023Submission Checks Completed
25 Aug 2023Assigned to Editor
25 Aug 2023Review(s) Completed, Editorial Evaluation Pending
28 Aug 2023Reviewer(s) Assigned
15 Sep 2023Editorial Decision: Revise Minor
08 Oct 20232nd Revision Received
09 Oct 2023Submission Checks Completed
09 Oct 2023Assigned to Editor
09 Oct 2023Review(s) Completed, Editorial Evaluation Pending
10 Oct 2023Reviewer(s) Assigned