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Reduced functional connectivity induced by longitudinal alterations of structure and perfusion may be associated with cognitive impairment in patients on maintenance hemodialysis
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  • Wenbo Yang,
  • Mingan Li,
  • Lijun Song,
  • Boyan Xu,
  • Qian Chen,
  • Zhenghan Yang,
  • Wenhu Liu,
  • Aihua Zhang,
  • Hao Wang,
  • Zhenchang Wang
Wenbo Yang
Capital Medical University Affiliated Beijing Friendship Hospital
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Mingan Li
Capital Medical University Affiliated Beijing Friendship Hospital
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Lijun Song
Capital Medical University Affiliated Beijing Friendship Hospital
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Boyan Xu
GE Healthcare
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Qian Chen
Capital Medical University Affiliated Beijing Friendship Hospital
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Zhenghan Yang
Capital Medical University Affiliated Beijing Friendship Hospital
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Wenhu Liu
Capital Medical University Affiliated Beijing Friendship Hospital
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Aihua Zhang
Capital Medical University Affiliated Beijing Friendship Hospital
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Hao Wang
Capital Medical University Affiliated Beijing Friendship Hospital

Corresponding Author:[email protected]

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Zhenchang Wang
Beijing Friendship Hospital, Capital Medical University
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Abstract

Background: Hemodialysis (HD) leads to cognitive impairment; however, the pathophysiology of maintenance HD remains unclear. This study aimed to investigate the longitudinal alterations in gray matter volume (GMV) and cerebral blood flow (CBF) in patients on follow-up HD compared with baseline HD, examine the alterations in functional connectivity (FC) by defining co-changed brain regions as seed points, and investigate the correlation between the co-changed brain regions and neuropsychological test scores. Methods: Twenty-seven patients with HD and 30 healthy controls were enrolled in this study. All participants underwent high-resolution T1-weighted imaging, arterial spin labeling, and functional MR imaging to measure GMV, CBF, and FC. The patients on HD were assessed at baseline and 3 years subsequently. Results: The right and left medial superior frontal gyrus (SFGmed.L) exhibited significantly lower GMV and CBF in patients on follow-up HD compared with patients on baseline HD and lower FC between the SFGmed.L and left middle temporal gyrus (MTG.L). Decreased FC between the SFGmed.L and MTG.L was positively correlated with neuropsychological test scores in the follow-up HD group. Conclusions: Reduced GMV and CBF may result in decreased FC between the SFGmed.L and MTG.L, which may be associated with cognitive impairment in patients on maintenance HD. Our findings provide unique insights into the pathological mechanisms of patients on maintenance HD with cognitive impairment.
24 Aug 2023Submitted to European Journal of Neuroscience
25 Aug 2023Submission Checks Completed
25 Aug 2023Assigned to Editor
25 Aug 2023Review(s) Completed, Editorial Evaluation Pending
25 Aug 2023Reviewer(s) Assigned