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Combining Brentuximab Vedotin with dexamethasone, high-dose cytarabine, and cisplatin (BV-DHAP) as salvage treatment in paediatric relapsed or refractory classical Hodgkin lymphoma: two case reports.
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  • Carmen Sinisi,
  • Paola Muggeo,
  • Rosa Angarano,
  • Rosa Maria Daniele,
  • Massimo Grassi,
  • Nicola Santoro
Carmen Sinisi
Universita degli Studi di Bari Aldo Moro Scuola di Medicina

Corresponding Author:[email protected]

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Paola Muggeo
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Rosa Angarano
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Rosa Maria Daniele
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Massimo Grassi
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Nicola Santoro
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Abstract

Hodgkin Lymphoma (HL) is a common malignancy in adolescents. For relapsed/refractory disease many regimens have been proposed and novel agents are increasingly used. Brentuximab Vedotin (BV) is an antiCD30 antibody-drug conjugate used as single agent or in combination with classical regimens mainly in adults, while limited is the experience in paediatrics. We report here on two boys with aggressive and high-risk relapsed HL, successfully treated with the BV plus DHAP regimen as induction salvage treatment. Our experience provides initial real-world evidence on the use of BV-DHAP as first-line salvage therapy for high-risk relapsed/refractory HL and expands the current therapeutic choices.