Children with home invasive mechanical ventilation face numerous difficulties, including endocrine problems that can arise as a consequence of their condition. Endocrine problems seen in children treated with HIMV may develop due to the underlying disease, drugs used, or prolonged mechanical ventilation. This manuscript will discuss the most common endocrine problems encountered in children with home invasive mechanical ventilation, including problems in glucose metabolism, thyroid dysfunction, bone metabolism, adrenal dysfunctions, growth and puberty. Close monitoring, multidisciplinary care, and regular assessments are essential to optimize the endocrin system functions of children requiring HMV. By understanding these complications, it can develop effective management strategies to optimize the health and well-being of these vulnerable individuals.