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Successful treatment of chest NUT-carcinoma in a paediatric patient with a novel NUTM1 rearrangement: case report and review of literature
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  • Francesco De leonardis,
  • Greco Miani Vittorio,
  • Marulli Giuseppe,
  • SABINA BARRESI,
  • Silvia Vallese,
  • Chiara Novielli,
  • Patrizia Dall'Igna,
  • Maruccia Michele,
  • Nicola Santoro
Francesco De leonardis
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari

Corresponding Author:[email protected]

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Greco Miani Vittorio
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Marulli Giuseppe
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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SABINA BARRESI
Ospedale Pediatrico Bambino Gesu
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Silvia Vallese
Ospedale Pediatrico Bambino Gesu
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Chiara Novielli
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Patrizia Dall'Igna
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Maruccia Michele
Universita degli Studi di Bari Aldo Moro Dipartimento dell'Emergenza e dei trapianti di organi
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Nicola Santoro
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
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Abstract

NUT carcinoma (NC) is an exceedingly rare and poorly differentiated carcinoma characterised by BDR4:NUTM1 gene translocation. It typically affects young adults, and due to its dismal clinical course, standardized therapeutic recommendations are lacking. In this study, we present a successful multimodal treatment approach for a 13-year-old boy diagnosed with primary chest NC harboring a novel NUTM1 rearrangement, achieving complete continuous remission 21 months after diagnosis.