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Prognostic value of the number of biopsied sentinel lymph nodes for Chinese patients with melanoma: A single-center retrospective study
  • +4
  • Tu Hu,
  • Yu Xu,
  • Wangjun Yan,
  • chun wang,
  • Wei Sun,
  • YunYi Kong,
  • Yong Chen
Tu Hu
Fudan University Shanghai Cancer Center Fudan University Cancer Institute
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Yu Xu
Fudan University Shanghai Cancer Center Fudan University Cancer Institute
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Wangjun Yan
Fudan University Shanghai Cancer Center Fudan University Cancer Institute
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chun wang
Fudan University Shanghai Cancer Center Fudan University Cancer Institute
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Wei Sun
Fudan University Shanghai Cancer Center Fudan University Cancer Institute
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YunYi Kong
Fudan University Shanghai Cancer Center
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Yong Chen
Fudan University Shanghai Cancer Center Fudan University Cancer Institute

Corresponding Author:[email protected]

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Abstract

Background: Sentinel lymph node biopsy (SLNB) helps to determine accurate pathological stages and facilitates strategies for regional disease control in melanoma. However, whether the number of biopsied sentinel lymph nodes (SLNs) influences the patients’ survival is rarely investigated. Methods: Acral or cutaneous melanoma patients with no history of nodal disease who received SLNB in Fudan University Shanghai Cancer Center (FUSCC) from January 1, 2017, to December 31, 2021 were retrospectively enrolled. Clinicopathological variables including Breslow index, ulceration, number of positive SLNs, SLN/non-SLN status were analyzed. Pathologic nodal (pN) stage and pathological stage were defined. Results: A total of 381 eligible patients were enrolled, of whom 132 (34.7%) patients were diagnosed with SLN-positive. The median number of biopsied SLNs was 2 (range: 1 to 20). Different numbers of biopsied SLNs did not influence the release-free survival (RFS) of the general patients. However, patients with > 2 SLNs had a longer RFS than those with 1-2 SLNs in T4, N1a group and those who rejected complete lymph node dissection (CLND). Conclusions: In patients with T4 melanomas, N1a melanomas and those that did not undergo a CLND, the prognosis of those with 3 or more SLNs retrieved seemed to be improved.
28 Jul 2023Submitted to Cancer Reports
31 Jul 2023Submission Checks Completed
31 Jul 2023Assigned to Editor
31 Jul 2023Review(s) Completed, Editorial Evaluation Pending
05 Aug 2023Reviewer(s) Assigned
16 Aug 2023Editorial Decision: Revise Major
14 Oct 20231st Revision Received
16 Oct 2023Submission Checks Completed
16 Oct 2023Assigned to Editor
16 Oct 2023Review(s) Completed, Editorial Evaluation Pending
18 Oct 2023Reviewer(s) Assigned
27 Oct 2023Editorial Decision: Revise Minor
10 Nov 20232nd Revision Received
11 Nov 2023Review(s) Completed, Editorial Evaluation Pending
11 Nov 2023Submission Checks Completed
11 Nov 2023Assigned to Editor