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Pre-transplant glomerular hyperfiltration is not a risk factor for increased renal morbidity and mortality in pediatric stem cell transplant patients
  • +2
  • Stefanie Benoit,
  • Neil Sarkar,
  • Kasiani Myers,
  • Adam Lane,
  • Stella Davies
Stefanie Benoit
Cincinnati Children's Hospital Medical Center Division of Bone Marrow Transplantation and Immune Deficiency

Corresponding Author:[email protected]

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Neil Sarkar
Wright State University Boonshoft School of Medicine
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Kasiani Myers
Cincinnati Children's Hospital Medical Center Division of Bone Marrow Transplantation and Immune Deficiency
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Adam Lane
Cincinnati Children's Hospital Medical Center Division of Bone Marrow Transplantation and Immune Deficiency
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Stella Davies
Cincinnati Children's Hospital Medical Center Division of Bone Marrow Transplantation and Immune Deficiency
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Abstract

Low glomerular filtration rate (GFR) prior to stem cell transplant (SCT) is associated with increased morbidity and mortality. The implications of abnormally high GFRs, or glomerular hyperfiltration, prior to SCT are unknown. Twenty two of 74 consecutive pediatric SCT patients over 2 years old at a single center were hyperfiltrating prior to SCT, median nuclear medicine GFR 154 mL/min/1.73 m 2 (IQR 146, 170). There was no association between any demographic and hyperfiltration, nor between hyperfiltration and acute kidney injury ( P = 0.8), renal replacement therapy ( P = 0.63), event-free survival ( P = 1), or chronic kidney disease ( P = 0.73).
22 Aug 2023Submitted to Pediatric Blood & Cancer
22 Aug 2023Submission Checks Completed
22 Aug 2023Assigned to Editor
22 Aug 2023Review(s) Completed, Editorial Evaluation Pending
24 Aug 2023Reviewer(s) Assigned
13 Sep 2023Editorial Decision: Revise Minor