In semiconductor manufacturing, metrology is generally a high cost, non-value added operation that impacts significantly on cycle time. As such, reducing wafer metrology continues to be a major target in semiconductor manufacturing efficiency initiatives. A novel data-driven spatial dynamic sampling methodology is presented that minimises the number of sites that need to be measured across a wafer surface while maintaining an acceptable level of wafer profile reconstruction accuracy. The methodology is based on analysing historical metrology data using Forward Selection Component Analysis (FSCA) to determine, from a set of candidate wafer sites, the minimum set of sites that need to be monitored in order to reconstruct the full wafer profile using statistical regression techniques. Dynamic sampling is then implemented by clustering unmeasured sites in accordance with their similarity to the FSCA selected sites, and temporally selecting a different sample from each cluster. In this way, the risk of not detecting previously unseen process behaviour is mitigated. We demonstrate the efficacy of the proposed methodology using both simulation studies and metrology data from a semiconductor manufacturing process.