AbstractPityriasis rubra pilaris (PRP) is a rare papulosquamous skin condition that affects both adults and the pediatric population. It is characterized by salmon-colored plaques with islands of sparing and palmoplantar hyperkeratosis. Currently, there are no established guidelines for PRP treatment, especially in pediatric patients. In this study, we presented an infant case of type III juvenile PRP successfully treated with a short-term, low-dose cyclosporine A (CsA). No recurrence occurred during the 3-month follow-up period after completing treatment. Additionally, we reviewed the use of CsA as an alternative treatment option for juvenile-onset PRP. The results of this study were consistent with previous findings for adult-onset PRP. Therefore, this study further supports using CsA as an alternative option for treating juvenile-onset PRP.