IntroductionA permcath is a long, flexible tube that is inserted into a vein, most commonly in the neck. It is mostly used as an alternative and long-term access in end-stage renal disease patients requiring hemodialysis. Pneumothorax, hemothorax, arrhythmias, and endocarditis are some of their complications (1). Kidney involvement with COVID-19 infection is a well-known complication, with the majority of them having acute tubular injury which resolved eventually. A few cases needed long-term hemodialysis and only a few cases had developed endocarditis due to permcath insertion with subsequent recovery (2). In this case report, we present a case of a 29-year-old man who has suffered from endocarditis after several hemodialyses through permcath due to COVID-19-induced renal failure.