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1064nm Nd:YAG laser promotes chondrocytes regeneration and cartilage reshaping by upregulating local estrogen levels
  • +8
  • Yingjie Zhu,
  • Xieling Peng,
  • Xueqing Zhou,
  • Hantao Li,
  • KHAING WIN,
  • Hongshun Wang,
  • Ziwei Guo,
  • Yang Xiong,
  • Jiaqi Xu,
  • Xiangrong Ni,
  • Xiangdong Qi
Yingjie Zhu
Zhujiang Hospital of Southern Medical University
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Xieling Peng
Zhujiang Hospital of Southern Medical University
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Xueqing Zhou
Zhujiang Hospital of Southern Medical University
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Hantao Li
Zhujiang Hospital of Southern Medical University
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KHAING WIN
Zhujiang Hospital of Southern Medical University
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Hongshun Wang
Zhujiang Hospital of Southern Medical University
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Ziwei Guo
Zhujiang Hospital of Southern Medical University
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Yang Xiong
Zhujiang Hospital of Southern Medical University
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Jiaqi Xu
Zhujiang Hospital of Southern Medical University
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Xiangrong Ni
Zhujiang Hospital of Southern Medical University
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Xiangdong Qi
Zhujiang Hospital of Southern Medical University

Corresponding Author:[email protected]

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Abstract

Cartilage is frequently used as scaffolds for repairing and reconstructing body surface organs. However, after successful plastic surgery, transplanted cartilage scaffolds often exhibit deformation and absorption over time. To enhance the shapping stability of cartilage scaffolds and improve patients’ satisfaction after reconstructions, we employed the ear folding models in New Zealand rabbit to confirm whether the 1064nm Nd:YAG laser could promote cartilage reshapping. There was an increase in collagen and aromatase (Cyp19) expression within the ear cartilage after laser treatment. Moreover, we have discovered that the Cyp19 inhibitor can suppress the shaping effect of the laser on cartilage, as well as the expression of collagen and Cyp19. The overall findings suggest that treatment with 1064nm Nd:YAG laser irradiation can enhance estrogen levels in local cartilage tissues by upregulating Cyp19 expression in chondrocytes through photobiomodulation, thereby promoting the proliferation and collagen secretion of chondrocytes to improve cartilage reshaping and stability.
24 Oct 2023Submitted to Journal of Biophotonics
24 Oct 2023Submission Checks Completed
24 Oct 2023Assigned to Editor
24 Oct 2023Review(s) Completed, Editorial Evaluation Pending
24 Oct 2023Reviewer(s) Assigned
15 Nov 2023Editorial Decision: Revise Major