Objective: The aim of this study is to investigate the prognostic correlation between tumor budding and stage I-II cervical cancer, with the goal of providing guidance for postoperative diagnosis and treatment strategies for patients.Methods: A comprehensive search was conducted across 12 databases including Pubmed, Cochrane, Embase, Scopus, OVID, Web of Science, EBSCohost, CNKI, Wan-Fang, VIP, Dui-Xiu and CBM to identify relevant literature on the association between tumor budding and prognosis or clinicopathological features of cervical cancer.The quality of included studies was assessed using the Newcastle-Ottawa scale. Statistical analysis was performed using Review Manager.Results: Our findings demonstrate that high-grade tumor budding in stage I-II cervical cancer is associated with significantly poorer overall survival (P<0.0001) and disease-free survival (P<0.0001). Subgroup analyses revealed that irrespective of sample size and histological type, the overall survival in the high-grade tumor budding group is markedly lower than that in the low-grade tumor budding group; similarly regardless of stage inclusion criteria, budding type, field boundary value or sample size,the disease-free survival in the high-grade tumor budding group is significantly lower than that in the low-grade tumor budding group.Furthermore,high grade tumor budding is correlated with several adverse pathological features.Conclusion: In light of these results,it can be concluded that tumor budding serves as an unfavorable prognostic factor for stage I-II cervical cancer,and may inform I-II stage postoperative treatment planning for such patients.

Objective: To explore the relationship between tumor budding and clinical pathological characteristics and prognosis of cervical cancer; Methods: By searching Pubmed, Embase, Cochren, CNKI and CBM databases, the research studies on the relationship between tumor budding and prognosis or clinic-pathological characteristics of cervical cancer were included. The quality of researches included was evaluated according the Castle Ottawa Scale (NOS) and statistically analyzed by Stata 12.0. Result: A total of 10 studies were included, including 11 cohorts. Including 2017 patients, the NOS score of these studies is more than 6 points. Tumor budding is related to age and tumor size of cervical cancer. In part of pathological characteristics, squamous cell carcinoma, higher stage, lymph node metastasis, distant metastasis, high WHO grade, deep interstitial invasion, Lymphatic vessel vascular space invasion, nerve invasion and para uterine invasion are more likely to occur tumor budding, occurrence of tumor sprouting in C-type cervical adenocarcinoma is higher than that in A/B type; In univariate analysis, there was a significant correlation between cervical cancer tumor sprouting and disease-free survival in patients (RR=6.511,P=0.000), in multivariate analysis, there was also a significant correlation between those (HR=3.358,P=0.001); Subgroup analysis of univariate analysis showed that Asian (RR=1.879, P=0.000), sample size ≤ 300 (RR=1.875, P=0.000), inclusion of squamous cell carcinoma (RR=1.884, P=0.000), staging criteria (FIGO and TNM), and tumor staging (I-II and mixed staging) all had an impact on DFS.Conclusion: The clinical application of tumor budding as a prognostic factor of cervical cancer can be considered.