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Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp3 C−H Bonds with Iodine (III)
  • +7
  • Hao Jia,
  • Nan Li,
  • Chunmei Tang,
  • Yajuan Wang,
  • Yonghao Xi,
  • Rongbao Liao,
  • Wei Xu,
  • Fufang Wu,
  • Xiaobao Shen,
  • Hongbin Zhai
Hao Jia
Fuyang Normal University
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Nan Li
Fuyang Normal University
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Chunmei Tang
Fuyang Normal University
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Yajuan Wang
Fuyang Normal University
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Yonghao Xi
Fuyang Normal University
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Rongbao Liao
Fuyang Normal University
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Wei Xu
Shenzhen Polytechnic
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Fufang Wu
Fuyang Normal University

Corresponding Author:[email protected]

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Xiaobao Shen
Fuyang Normal University
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Hongbin Zhai
Peking University Shenzhen Graduate School
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Abstract

A metal-free, green, and sustainable functionalization of unactivated alkyl sp3 C–H bonds is reported using iodine (III) as a feasible dehydrogenation agent under visible light or KBr, and alkyl chlorides, bromides, alcohols, and ketones could be constructed by addi-tion of different coupling reagents. Cheap and safe iodobenzene diacetate was used to form a strong radical to activate the alkyl sp3 C–H bond in a highly efficient manner, which can construct different alkylation products by adding corresponding coupling reagents.
03 Nov 20231st Revision Received
03 Nov 2023Submission Checks Completed
03 Nov 2023Assigned to Editor
03 Nov 2023Review(s) Completed, Editorial Evaluation Pending
04 Nov 2023Editorial Decision: Accept