Wireless fidelity (WiFi) and long term evolution (LTE) coexistence system has attracted significant attention recently. However, most studies on coexistence only consider the issues about downlink performance and fairness between WiFi network and LTE network. In this paper, we take a comprehensive consideration of both the performance of WiFi and LTE, to propose a downlink/uplink decoupling (DUDe) scheme for the fairness of the coexistence system. Through the process of modeling construction, problem formulation with reformulation, solution and simulations, we illustrate that DUDe can achieve proportional fairness in terms of sum throughput and load balancing between uplink and downlink. In our decoupling model for coexistence between WiFi and LTE, resource allocation is under adaptive spectrum partitioning and users can access each network of WiFi and LTE. Moreover, to make our proposal more realistic, we adopt support vector machine (SVM) to predict the total number of users in WiFi and LTE coexistence system, where the predictive simulation shows its high prediction accuracy with low complexity. We further apply the prediction results to the optimization problem of DUDe. Simulation results manifest that the proposed DUDe scheme has better performance in terms of sum throughput. The sum throughput of DUDe scheme can come up to almost twice more than that of coupled association scheme. The result shows that DUDe can also achieve load balance between uplink and downlink in the coexistence system.