Electrocatalytic reduction of CO2 into high energy-density fuels and value-added chemicals under mild conditions can promote the sustainable cycle of carbon and decrease current energy and environmental problems. Constructing electrocatalyst with high activity, selectivity, stability and low cost is really matter to realize industrial application of electrocatalytic CO2 reduction (ECR). Metal-nitrogen-carbon (M-N-C) electrocatalysts, especially Ni-N-C, display excellent performance, such as nearly 100% CO selectivity, high current density, outstanding tolerance, etc., which is considered to possess broad application prospects. Based on the current research status, starting from the mechanism of ECR and the existence form of Ni active species, the latest research progress of Ni-N-C electrocatalysts in CO2 electroreduction is systematically summarized. An overview is emphatically interpreted on the regulatory strategies for activity optimization over Ni-N-C, including N coordination modulation, vacancy defects construction, morphology design, surface modification, heteroatom activation, bimetallic cooperation. Finally, some urgent problems and future prospects on designing Ni-N-C catalyst for ECR are discussed. This review aims to provide the guidance for the design and development of Ni-N-C catalyst with practical application.